Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways
Hepatology2008Vol. 48(3), pp. 909–919
Citations Over TimeTop 10% of 2008 papers
Abstract
CLDH have increased vimentin and type 1 collagen expression and morphologic features consistent with EMT. In addition, compared to NLDH, the cellular signaling phenotype of CLDH changes from a MAPK-independent pathway to a MAPK-dependent cell survival pathway. These findings may have clinical implications for chemoprevention of hepatocellular carcinoma in the cirrhotic liver.
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