MicroRNA‐23b cluster microRNAs regulate transforming growth factor‐beta/bone morphogenetic protein signaling and liver stem cell differentiation by targeting Smads†
Hepatology2009Vol. 50(2), pp. 575–584
Citations Over TimeTop 10% of 2009 papers
Charles E. Rogler, Lauretta LeVoci, Tammy Ader, Aldo Massimi, Tatyana Tchaikovskaya, Raquel Norel, Leslie E. Rogler
Abstract
Our data provide a model in which miR-23b miRNAs repress bile duct gene expression in fetal hepatocytes while promoting their growth by down-regulating Smads and consequently TGFbeta signaling. Concomitantly, low levels of the miR-23b miRNAs are needed in cholangiocytes to allow TGFbeta signaling and bile duct formation.
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