Endotoxin Accumulation Prevents Carcinogen-Induced Apoptosis and Promotes Liver Tumorigenesis in Rodents
Hepatology2010Vol. 52(4), pp. 1322–1333
Citations Over TimeTop 10% of 2010 papers
Le‐Xing Yu, He‐Xin Yan, Qiong Liu, Wen Yang, Hongping Wu, Wei Dong, Liang Tang, Yan Lin, Yaqin He, Shan–Shan Zou, Chao Wang, Hui‐Lu Zhang, Guangwen Cao, Mengchao Wu, Hongyang Wang
Abstract
Our data indicate that sustained LPS accumulation represents a pathological mediator of inflammation-associated hepatocellular carcinoma (HCC) and manipulation of the gut flora to prevent pathogenic bacterial translocation and endotoxin absorption may favorably influence liver function in patients with cirrhosis who are at risk of developing HCC.
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