Coffee Reduces Liver Damage in a Rat Model of Steatohepatitis: The Underlying Mechanisms and the Role of Polyphenols and Melanoidins
Hepatology2010Vol. 52(5), pp. 1652–1661
Citations Over TimeTop 10% of 2010 papers
Paola Vitaglione, Filomena Morisco, G. Mazzone, Daniela Caterina Amoruso, M. Ribecco, Antonietta Romano, Vincenzo Fogliano, N. Caporaso, Giuseppe D’Argenio
Abstract
Our data demonstrate that coffee consumption protects the liver from damage caused by a high-fat diet. This effect was mediated by a reduction in hepatic fat accumulation (through increased fatty acid β-oxidation); systemic and liver oxidative stress (through the glutathione system); liver inflammation (through modulation of genes); and expression and concentrations of proteins and cytokines related to inflammation.
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