Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis
Hepatology2010Vol. 53(1), pp. 209–218
Citations Over TimeTop 1% of 2010 papers
Christoph Roderburg, Gerd-Willem Urban, Kira Bettermann, Mihael Vucur, Henning W. Zimmermann, Sabine Schmidt, Jörn Janssen, Christiane Koppe, Percy A. Knolle, M. Castoldi, Frank Tacke, Christian Trautwein, Tom Luedde
Abstract
Our data indicate that miR-29 mediates the regulation of liver fibrosis and is part of a signaling nexus involving TGF-β- and NF-κB-dependent down-regulation of miR-29 family members in HSC with subsequent up-regulation of extracellular matrix genes. Thus they may represent targets for novel therapeutic strategies against hepatic fibrogenesis and also might evolve as biomarkers in the diagnosis of liver fibrosis.
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