Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells
Hepatology2010Vol. 53(1), pp. 148–159
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Mei Chuan Chen, Chun‐Han Chen, Chun‐Han Chen, Hsiao-Ching Chuang, Samuel K. Kulp, Ching-Shih Chen, Ching-Shih Chen, Ching-Shih Chen
Abstract
This study shows a novel pathway by which HDAC inhibitors facilitate the selective degradation of topoIIα, which underlies the complexity of the functional role of HDAC in regulating tumorigenesis and aggressive phenotype in HCC cells.
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