Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans
Hepatology2012Vol. 56(2), pp. 735–746
Citations Over TimeTop 1% of 2012 papers
Charalambos G. Antoniades, Alberto Quaglia, Leonie S. Taams, Ragai R. Mitry, Munther J. Hussain, R.D. Abeles, Lucia Possamai, Matthew Bruce, Mark McPhail, Chris Starling, Bart Wagner, Adrian Barnardo, Sabine Pomplun, Georg Auzinger, William Bernal, Nigel Heaton, Diego Vergani, Mark Thursz, Julia Wendon
Abstract
In AALF, the h-mφ population is expanded in areas of necrosis, both through proliferation of resident cells and CCL2-dependent recruitment of circulating monocytes. The presence of h-mφ within an anti-inflammatory/regenerative microenvironment indicates that they are implicated in resolution of inflammation/tissue repair processes during AALF.
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