Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma
Hepatology2012Vol. 56(5), pp. 1792–1803
Citations Over TimeTop 1% of 2012 papers
Naoki Oishi, Mia R. Kumar, Stéphanie Roessler, Junfang Ji, Marshonna Forgues, Anuradha Budhu, Xuelian Zhao, Jesper B. Andersen, Qing hai Ye, Hu Jia, Lun Qin, Taro Yamashita, Hyun Goo Woo, Yoon Jun Kim, Shuichi Kaneko, Zhao-You Tang, Snorri S. Thorgeirsson, Xin Wei Wang
Abstract
Our results indicate that ICC and HCC share common stem-like molecular characteristics and poor prognosis. We suggest that the specific components of EMT may be exploited as critical biomarkers and clinically relevant therapeutic targets for an aggressive form of stem cell-like ICC.
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