Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development
Hepatology2012Vol. 56(6), pp. 2255–2267
Citations Over TimeTop 10% of 2012 papers
Kun Wu, Jin Ding, Cheng Chen, Wen Sun, Beifang Ning, Wen Wen, Lei Huang, Tao Han, Wen Yang, Chao Wang, Li Zhong, Mengchao Wu, Gen‐Sheng Feng, Wei‐Fen Xie, Hongyang Wang
Abstract
Hepatoma-initiating cells may derive from hepatic progenitor cells exposed to chronic and constant TGF-β stimulation in cirrhotic liver, and pharmaceutical inhibition of microRNA-216a/PTEN/Akt signaling could be a novel strategy for HCC prevention and therapy targeting hepatic T-ICs.
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