The Postbinding Activity of Scavenger Receptor Class B Type I Mediates Initiation of Hepatitis C Virus Infection and Viral Dissemination
Hepatology2012Vol. 57(2), pp. 492–504
Citations Over TimeTop 10% of 2012 papers
Muhammad Zahid, Marine Turek, Fei Xiao, Viet Loan Dao Thi, Maryse Guérin, Isabel Fofana, Philippe Bachellier, John S. Thompson, Leen Delang, Johan Neyts, Dorothea Bankwitz, Thomas Pietschmann, Marlène Dreux, François–Loïc Cosset, Fritz Grunert, Thomas F. Baumert, Mirjam B. Zeisel
Abstract
Taken together, our results uncover a crucial role of the SR-BI postbinding function for initiation and maintenance of viral HCV infection that does not require receptor-E2/HDL interactions. The dissection of the molecular mechanisms of SR-BI-mediated HCV entry opens a novel perspective for the design of entry inhibitors interfering specifically with the proviral function of SR-BI.
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