Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury
Hepatology2012Vol. 57(5), pp. 1773–1783
Citations Over TimeTop 1% of 2012 papers
Abstract
CYP2E1-dependent RIP3 expression induces hepatocyte necroptosis during ethanol feeding. Ethanol-induced hepatocyte injury is RIP3-dependent, but independent of RIP1 kinase activity; intervention of this pathway could be targeted as a potential therapeutic strategy.
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