Mechanistic Biomarkers Provide Early and Sensitive Detection of Acetaminophen-Induced Acute Liver Injury at First Presentation to Hospital
Hepatology2013Vol. 58(2), pp. 777–787
Citations Over TimeTop 1% of 2013 papers
Daniel J. Antoine, James W. Dear, Philip Starkey Lewis, Vivien Platt, J. Terrence Coyle, M Masson, Ruben Thanacoody, Alasdair Gray, David J. Webb, Jonathan G. Moggs, D. Nicholas Bateman, Christopher E. Goldring, Kevin B. Park
Abstract
Elevations in plasma miR-122, HMGB1, and necrosis K18 identified subsequent ALI development in patients on admission to the hospital, soon after acetaminophen overdose, and in patients with ALTs in the normal range. The application of such a biomarker panel could improve the speed of clinical decision-making, both in the treatment of ALI and the design/execution of patient-individualized treatment strategies.
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