ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury
Hepatology2013Vol. 58(1), pp. 351–362
Citations Over TimeTop 10% of 2013 papers
Naoko Kamo, Bibo Ke, Amir A. Ghaffari, Xiu‐Da Shen, Ronald W. Busuttil, Genhong Cheng, Jerzy W. Kupiec‐Weglinski
Abstract
ASC-mediated caspase-1/IL-1β signaling promotes HMGB1 to produce a TLR4-dependent inflammatory phenotype and leads to hepatocellular injury. Hence, ASC/caspase-1/IL-1β signaling mediates the inflammatory response by triggering HMGB1 induction in hepatic IRI. Our findings provide a rationale for a novel therapeutic strategy for managing liver injury due to IR.
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