Kinetic differences in the induction of interferon stimulated genes by interferon-α and interleukin 28B are altered by infection with hepatitis C virus
Hepatology2013Vol. 59(4), pp. 1250–1261
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Nikolaus Jilg, Wenyu Lin, Jian Hong, Esperance Schaefer, David Wolski, James Meixong, Kaku Goto, Cynthia Brisac, Pattranuch Chusri, Dahlene N. Fusco, Stéphane Chevaliez, Jay Luther, Kattareeya Kumthip, Thomas Urban, Lee F. Peng, Georg M. Lauer, Raymond T. Chung
Abstract
The kinetics of gene induction are fundamentally different for stimulations with either IFN-α or IL28B in hepatocytes, suggesting distinct roles of these cytokines within the immune response. Furthermore, the observed differences are substantially altered by infection with HCV.
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