Oncofetal long noncoding RNA PVT1 promotes proliferation and stem cell-like property of hepatocellular carcinoma cells by stabilizing NOP2
Hepatology2014Vol. 60(4), pp. 1278–1290
Citations Over TimeTop 1% of 2014 papers
Fang Wang, Ji‐hang Yuan, Shao-Bing Wang, Fu Yang, Sheng-Xian Yuan, Chen Ye, Ning Yang, Wei-Ping Zhou, Wen-Lin Li, Wen Li, Shu-Han Sun
Abstract
Our study demonstrates that the expression of many lncRNAs is up-regulated in early liver development and that the fetal liver can be used to search for new diagnostic markers for HCC. LncRNA-hPVT1 promotes cell proliferation, cell cycling, and the acquisition of stem cell-like properties in HCC cells by stabilizing NOP2 protein. Regulation of the lncRNA-hPVT1/NOP2 pathway may have beneficial effects on the treatment of HCC.
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