Differentiation therapy for hepatocellular carcinoma: Multifaceted effects of miR‐148a on tumor growth and phenotype and liver fibrosis
Hepatology2015Vol. 63(3), pp. 864–879
Citations Over TimeTop 10% of 2015 papers
Kwang Hwa Jung, Jing Zhang, Chong Zhou, Hong Shen, Mihai Gagea, Cristian Rodriguez‐Aguayo, Gabriel Lopez‐Berestein, Anil K. Sood, Laura Beretta
Abstract
miR-148a is an inhibitor of the IκB kinase alpha/NUMB/NOTCH pathway and an inducer of hepatocytic differentiation that when deregulated promotes HCC initiation and progression. Differentiation-targeted therapy may be a promising strategy to treat and prevent HCC.
Related Papers
- → The role of NUMB/NUMB isoforms in cancer stem cells(2021)33 cited
- → Numb Expression and Asymmetric versus Symmetric Cell Division in Distal Embryonic Lung Epithelium(2012)20 cited
- → [Advances in research on cell fate determinant Numb regulating liver cancer].(2018)2 cited
- A Comparison Analysis between the Expressions of Serum MiR-200a and AFP in Liver Cirrhosis and Liver Cancer Patients(2012)
- → Role of Numb in tumors(2012)