RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2
Hepatology2017Vol. 67(6), pp. 2254–2270
Citations Over TimeTop 1% of 2017 papers
Mengnuo Chen, Lai Wei, Cheuk‐Ting Law, Felice Ho‐Ching Tsang, Jialing Shen, Carol Lai‐Hung Cheng, Long‐Hin Tsang, Daniel Wai‐Hung Ho, David Kung‐Chun Chiu, Joyce Man‐Fong Lee, Carmen Chak‐Lui Wong, Irene Oi‐Lin Ng, Chun‐Ming Wong
Abstract
METTL3 is frequently up-regulated in human HCC and contributes to HCC progression. METTL3 represses SOCS2 expression in HCC through an m6A-YTHDF2-dependent mechanism. Our findings suggest an important mechanism of epigenetic alteration in liver carcinogenesis. (Hepatology 2018;67:2254-2270).
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