Single‐Cell Transcriptomic Analysis Reveals a Hepatic Stellate Cell–Activation Roadmap and Myofibroblast Origin During Liver Fibrosis in Mice
Hepatology2021Vol. 74(5), pp. 2774–2790
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Yang Wu, Hao He, Tongtong Wang, Nan Su, Feng Zhang, Kai Jiang, Jing Zhu, Chonghe Zhang, Kongyan Niu, Luyue Wang, Xiaodong Yuan, Nan Liu, Lingjie Li, Wei Wu, Junhao Hu
Abstract
This study provides a transcriptional roadmap for the activation of HSCs during liver fibrosis and yields comprehensive evidence that the differential transcriptomic features of HSCs and PFs, along with their relative contributions to liver fibrosis of different etiologies, should be considered in developing effective antifibrotic therapeutic strategies.
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