The Serum Proteome and Ursodeoxycholic Acid Response in Primary Biliary Cholangitis
Hepatology2021Vol. 74(6), pp. 3269–3283
Citations Over TimeTop 10% of 2021 papers
Ben Barron‐Millar, Laura Ogle, George Mells, Steven Flack, Jonathan Badrock, Richard Sandford, John A. Kirby, Jeremy M. Palmer, Laura Jopson, John Brain, Graham R. Smith, Steve Rushton, Vinod S. Hegade, Rebecca Jones, Simon Rushbrook, Douglas Thorburn, Steve Ryder, Gideon M. Hirschfield, Jessica Dyson, David E.J. Jones
Abstract
UDCA under-response in PBC is characterized by elevation of serum chemokines potentially related to cellular senescence and was previously shown to be released by BECs in PBC, suggesting a potential role in the pathogenesis of high-risk disease. These also have potential for development as biomarkers for identification of high-risk disease, and their clinical utility as biomarkers should be evaluated further in prospective studies.
Related Papers
- → Ursodeoxycholic acid inhibits the induction of nitric oxide synthase(1996)20 cited
- → Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy(2000)9 cited
- → The effectual level of ursodeoxycholic acid in therapy for non-advanced chronic cholestasis is fifty percent of total serum bile acids(1992)2 cited
- Application of ursodeoxycholic acid for the treatment of cholestatic liver diseases(2008)
- [Ursodeoxycholic acid in primary biliary cirrhosis. 1: Therapeutic approaches up to now and the rationale for treatment with ursodeoxycholic acid].(1988)