Hepatocyte‐specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin‐like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice
Hepatology2021Vol. 75(1), pp. 125–139
Citations Over TimeTop 10% of 2021 papers
Claudia Fuchs, Richard Radun, Emmanuel D. Dixon, Veronika Mlitz, Gerald Timelthaler, Emina Halilbasic, Merima Herac, Johan W. Jonker, Onne A. H. O. Ronda, Matteo Tardelli, Guenter Haemmerle, Robert Zimmermann, Hubert Scharnagl, Tatjana Stojaković, Henkjan J. Verkade, Michael Trauner
Abstract
Low hepatic lipolysis and increased PPARδ activity in ATGL/PNPLA2 deficiency may counteract hepatic inflammation and ER stress despite increased steatosis. Therefore, lowering hepatocyte lipolysis through ATGL inhibition represents a promising therapeutic strategy for the treatment of steatohepatitis.
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