Activation of an IL-6:STAT3-dependent transcriptome in pediatric-onset inflammatory bowel disease
Inflammatory Bowel Diseases2007Vol. 14(4), pp. 446–457
Citations Over TimeTop 10% of 2007 papers
Rebecca G. Carey, Ingrid Jurickova, Edgar T. Ballard, Erin Bonkowski, Xiaonan Han, Huan Xu, Lee A. Denson
Abstract
A proinflammatory IL6:STAT3 biologic network is upregulated in active pediatric IBD patients at diagnosis and during therapy. Specific targeting of this network may be effective in reducing mucosal inflammation.
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