Angiopoietin-2 in experimental colitis
Inflammatory Bowel Diseases2009Vol. 16(6), pp. 1029–1039
Citations Over TimeTop 10% of 2009 papers
Vijay C. Ganta, Walter Cromer, Ginny L. Mills, James Traylor, Merilyn H. Jennings, Sarah Daley, Benjamin Clark, J. Michael Mathis, Michael Bernas, Moheb Boktor, Paul Jordan, Marlys H. Witte, Steven Alexander
Abstract
These data demonstrate that in DSS colitis, Ang-2 mediates inflammatory hemangiogenesis, lymphangiogenesis and neutrophil infiltration to reduce some, but not all clinical features of IBD. The implications for Ang-2 manipulation in the development of IBD and other inflammatory diseases and treatments involving Ang-2 are discussed.
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