Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis
Inflammatory Bowel Diseases2010Vol. 17(2), pp. 532–542
Citations Over TimeTop 10% of 2010 papers
Sundaram Ramasamy, Deanna D. Nguyen, Michelle A. Eston, Sayeda Nasrin Alam, Angela K. Moss, Farzad Ebrahimi, Brishti Biswas, Golam Mostafa, Kathryn T. Chen, Kanakaraju Kaliannan, Halim Yammine, Sonoko Narisawa, José Luís Millán, S. Warren, Elizabeth Hohmann, Emiko Mizoguchi, Hans-Christian Reinecker, Atul K. Bhan, Scott B. Snapper, Madhu S. Malo, Richard A. Hodin
Abstract
Endogenous IAP appears to play a role in protecting the host against chronic colitis. Orally administered cIAP exerts a protective effect in two independent mouse models of chronic colitis and may represent a novel therapy for human IBD.
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