Matriptase Protects Against Experimental Colitis and Promotes Intestinal Barrier Recovery
Inflammatory Bowel Diseases2011Vol. 18(7), pp. 1303–1314
Citations Over TimeTop 11% of 2011 papers
Sarah Netzel–Arnett, Marguerite S. Buzza, Terez Shea‐Donohue, Antoine Désilets, Richard Leduc, Alessio Fasano, Thomas Bugge, Toni Antalis
Abstract
These data demonstrate a critical role for matriptase in restoring barrier function to injured intestinal mucosa during colitis, which is suppressed by excessive activation of the immune system. Strategies to enhance matriptase-mediated barrier recovery could be important for intervening in the cycle of inflammation associated with IBD.
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