Colorectal cancer survival in sub‐Saharan Africa by age, stage at diagnosis and Human Development Index: A population‐based registry study

Citations Over TimeTop 10% of 2021 papers

Abstract

Abstract There are limited population‐based survival data for colorectal cancer (CRC) in sub‐Saharan Africa. Here, 1707 persons diagnosed with CRC from 2005 to 2015 were randomly selected from 13 population‐based cancer registries operating in 11 countries in sub‐Saharan Africa. Vital status was ascertained from medical charts or through next of kin. 1‐, 3‐ and 5‐year overall and relative survival rates for all registries and for each registry were calculated using the Kaplan‐Meier estimator. Multivariable analysis was used to examine the associations of 5‐year relative survival with age at diagnosis, stage and country‐level Human Development Index (HDI). Observed survival for 1448 patients with CRC across all registries combined was 72.0% (95% CI 69.5‐74.4%) at 1 year, 50.4% (95% CI 47.6‐53.2%) at 3 years and 43.5% (95% CI 40.6‐46.3%) at 5 years. We estimate that relative survival at 5 years in these registry populations is 48.2%. Factors associated with poorer survival included living in a country with lower HDI, late stage at diagnosis and younger or older age at diagnosis (<50 or ≥70 years). For example, the risk of death was 1.6 (95% CI 1.2‐2.1) times higher for patients residing in medium‐HDI and 2.7 (95% CI 2.2‐3.4) times higher for patients residing in low‐HDI compared to those residing in high‐HDI countries. Survival for CRC remains low in sub‐Saharan African countries, though estimates vary considerably by HDI. Strengthening health systems to ensure access to prevention, early diagnosis and appropriate treatment is critical in improving outcomes of CRC in the region.

Related Papers

• → Measuring the effect of including multiple cancers in survival analyses using data from the Canadian Cancer Registry(2010)30 cited
• Survival analysis of 2003-2005 data from the population-based Cancer Registry in Macao.(2010)
• → Population-based study of short- and long-term survival from colorectal cancer in Denmark, 1977–1999(2005)20 cited
• Breast cancer survival in Rizal, Philippines, 1996-1997.(2011)
• [Five-year relative survival rates in Swietokrzyskie voivodeship (Poland) on the basis of the Swietokrzyskie Cancer Registry data].(2011)