Genistein treatment protects mice from ionizing radiation injury
Citations Over TimeTop 10% of 2003 papers
Abstract
The radioprotective and behavioral effects of an acute administration of the isoflavone genistein (4',5,7-trihydroxyflavone) were investigated in adult CD2F1 male mice. Mice were administered a single subcutaneous (s.c.) dose of genistein either 24 h or 1 h before a lethal dose of gamma radiation (9.5-Gy of cobalt-60 at 0.6 Gy min(-1)). Mice received saline, PEG-400 vehicle or genistein at 3.125, 6.25, 12.5, 25, 50, 100, 200, or 400 mg kg(-1) body weight. For mice treated 24 h before irradiation there was a significant increase in 30-day survival for animals receiving genistein doses of 25 to 400 mg kg(-1) (p<0.001). In contrast, the 30-day survival rates of mice treated with genistein 1 h before irradiation were not significantly different from those of the vehicle control group. Additionally, the acute toxicity of genistein was evaluated in non-irradiated male mice administered a single s.c. injection of saline, vehicle, or genistein at 100, 200 or 400 mg kg(-1). At these genistein doses there were no adverse effects, compared with controls, on locomotor activity, grip strength, motor coordination, body weight, testes weight, or histopathology. These results demonstrate that a single s.c. administration of the flavonoid genistein at non-toxic doses provides protection against acute radiation injury.
Related Papers
- → Biochemical Targets of the Isoflavone Genistein in Tumor Cell Lines(1995)166 cited
- → Signal Transduction Pathway Regulated by Genistein and its Therapeutic Use(2008)1 cited
- Synthesis of Genistein Sulfates and Effects of Genistein and its Sulfates on Proliferation of Breast Cancer Cells(2011)
- → Dietary genistein generates reduced blood pressure in female mice.(2006)
- 국제콩심포지움 ' 21 세기 인류건강을 위한 콩 ' ( International Soybean Symposium - Soya Power for Active and Healthy Life in the 21st Century ) : 유방암에 대한 제니스타인의 효과 - 화학적 예방요법 , 생체작용 기작과 생체 이용법 -(1998)