Multiple Functions of Long Non‐Coding RNAs in Oxidative Stress, DNA Damage Response and Cancer Progression

Citations Over TimeTop 10% of 2017 papers

Abstract

In addition to aberrant alternation of transcriptome, it is now suggested that dysregulation of the non-coding transcripts, particularly long non-coding RNAs (lncRNAs), which comprise the majority of the genome, is contributed to cancer initiation and progression. As the result of recent huge efforts, the possible roles of numerous lncRNAs in the human cancers were characterized, as well as various strategies with inhibitory effects to target these transcripts on the transformed cells. Moreover, DNA damage response (DDR) pathway is a complex regulatory network responsible for the identification of disruptions in DNA structure, integrity and stability- it is reported to be associated with the up-regulation and down-regulation of lncRNAs. This review explores the involvement of the various lncRNAs in different human cancers, afterwards discusses the association of the lncRNAs expression with the DDR and oxidative stress, which are implicated in a myriad pathophysiological and physiological intra- and extracellular damages. J. Cell. Biochem. 119: 223-236, 2018. © 2017 Wiley Periodicals, Inc.

Related Papers

• → Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress(2014)238 cited
• → DNA Damage in Cancer Therapeutics: A Boon or a Curse?(2015)139 cited
• → Induction of DNA damage and erroneous repair can explain genomic instability caused by endosulfan(2016)52 cited
• → DNA damage in cells exhibiting radiation-induced genomic instability(2015)14 cited
• → The role of progesterone-induced blocking factor (PIBF) in invasion of primary ovarian tumour cells(2017)