Risk factors for prolonged virus shedding of respiratory tract and fecal in adults with severe acute respiratory syndrome coronavirus‐2 infection
Journal of Clinical Laboratory Analysis2021Vol. 35(9), pp. e23923–e23923
Citations Over TimeTop 24% of 2021 papers
Shun Zhang, Hui Zhu, Honghua Ye, Yaoren Hu, Nanhong Zheng, Zuoan Huang, Zi Xiong, Liyun Fu, Ting Cai
Abstract
Obesity, delayed antiviral treatment, and positive SARS-CoV-2 for stool were independent risk factors for prolonged SARS-CoV-2 RNA shedding of the respiratory tract. A combination of LPV/r and abidol as the initial antiviral regimen was effective in shortening the duration of viral shedding compared with LPV/r combined with chloroquine phosphate. CD4+ T cell and NK cells were significantly associated with prolonged viral shedding, and further studies are to be warranted to determine the mechanism of immunomodulatory response in virus clearance.
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