Circulating visfatin levels and cancers risk: A systematic review and meta‐analysis

Citations Over TimeTop 10% of 2018 papers

Abstract

Visfatin levels have been reported to be abnormal in many types of cancers. However, epidemiological studies yielded inconsistent results. Therefore, a meta-analysis was performed to assess the association between circulating visfatin levels and cancer risk. A systematic search was conducted for relevant studies in health-related electronic databases up to March 2018. Data related to standard mean difference (SMD) and overall odds ratio (ORS) were collected and analyzed. Summary SMD and pooled OR with 95% CIs were calculated using a random-effect model. Funnel plot and Egger's linear regression test were conducted to examine the risk of publication bias. A total of 27 studies with 2,693 cases and 3,040 healthy controls were included in meta-analysis for pooling SMD analysis. The results of the meta-analysis showed a significant higher visfatin levels in patients with various cancers than in controls, with a pooled SMD of 0.88, 95% CI = 0.56-1.20, p = 0.000. In subgroup, metaregression, Galbraith plot, and sensitivity analysis showed no substantial difference among all the analyzed factors. Data from 14 studies were also used for pooling ORs analysis. Metaresults revealed that high visfatin levels were associated with cancer risk (OR = 1.24, 95% CI: 1.14-1.34, p = 0.000). No evidence of publication bias was observed for pooling ORs and SMD analysis. This meta-analysis indicated a significant association between high circulating visfatin levels and increased risk of various cancers. Visfatin may represent a potential biomarker for early detection of cancers who may benefit from preventive treatment.Note.

Related Papers

• → Passive Smoking and Cervical Cancer Risk: A Meta-analysis Based on 3,230 Cases and 2,982 Controls(2012)73 cited
• → Increased carotid intima–media thickness (CIMT) levels in patients with type 1 diabetes mellitus (T1DM): A meta-analysis(2015)23 cited
• → Prevention of Blood Donation-related Vasovagal Response by Applied Muscle Tension: a Meta-analysis(2022)9 cited
• → The effect of school intervention programs on the body mass index of adolescents: a systematic review with meta-analysis(2020)6 cited
• → Association Between Major Depression And Type 2 Diabetes Mellitus: A Meta-Analysis And Meta-Regression Of Observational Studies(2016)3 cited