Inhibition of connective tissue growth factor by siRNA prevents liver fibrosis in rats
The Journal of Gene Medicine2006Vol. 8(7), pp. 889–900
Citations Over TimeTop 10% of 2006 papers
Guangming Li, Qing Xie, Yi Shi, Dingguo Li, Mingjun Zhang, Shan Jiang, Huijuan Zhou, Han‐Ming Lu, Youxin Jin
Abstract
Silencing CTGF expression with siRNA demonstrates therapeutic potential to prevent liver fibrosis by inhibiting HSC activation with consequent extracellular matrix accumulation and the upregulation of TGF-beta1 gene expression.
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