Enhanced gene expression through temperature profile‐induced variations in molecular architecture of thermoresponsive polymer vectors
The Journal of Gene Medicine2006Vol. 9(1), pp. 44–54
Citations Over TimeTop 22% of 2006 papers
Matthieu D. Lavigne, Sivanand S. Pennadam, J. S. Ellis, Laura L. Yates, Cameron Alexander, Dariusz C. Górecki
Abstract
Designed changes in thermoresponsive polycation vector configuration via temperature-induced phase transitions enhanced transgene expression. The results indicate that changes in molecular architecture induced by a carefully chosen stimulus during intracellular trafficking can be used to enhance gene delivery.
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