Identification of lignans by liquid chromatography‐electrospray ionization ion‐trap mass spectrometry

Citations Over TimeTop 16% of 2007 papers

Abstract

The fragmentation pattern of 30 compounds belonging to different classes of the lignan family was studied by liquid chromatography-electrospray ionization ion-trap mass spectrometry. On the basis of the observed fragmentation patterns, identification of different types of lignans was achieved. For example, dibenzylbutyrolactone lignans showed a characteristic fragmentation pathway by the loss of 44 Da (CO(2)) from the lactone moiety, whereas dibenzylbutanediols showed a loss of 48 Da by a combined loss of formaldehyde and water from the 1,4-butanediol moiety. Lignan glycosides readily lost the sugar residue to give the parent lignan as their primary product ion. In addition, several compound-specific fragmentations were observed and used for identification of individual compounds.A versatile method for analyses of lignans was developed using LC separation on a C8 column followed by fragmentation and detection of ions produced in the ion trap.

Related Papers

• → Analytical Characterization of the Electrospray Ion Source in the Nanoflow Regime(2008)90 cited
• → Synchronized dual-polarity electrospray ionization mass spectrometry(2009)8 cited
• → Achieving Augmented Limits of Detection for Peptides with Hydrophobic Alkyl Tags(2007)45 cited
• → Suppression of Protein Structural Perturbations in Native Electrospray Ionization during the Final Evaporation Stages Revealed by Molecular Dynamics Simulations(2021)11 cited
• → Electro-kinetic assisted electrospray ionization for enhanced complex sample analysis(2016)10 cited