Future perspective of nanoparticle interaction‐assisted laser desorption/ionization mass spectrometry for rapid, simple, direct and sensitive detection of microorganisms
Abstract
In the years since the introduction of MALDI, a number of approaches have been explored to enhance the effi ciency of laser desorption/ionization and to reduce the number of matrix-related background ions that populate a MALDI spectrum. Some strategies have been to tailor the desorption/ionization properties of a matrix by combining two or more compounds or by modifying existing functional groups. Professor Hui-Fen Wu's group has been actively exploring the use of nanoparticles both as a matrix additive and as the sole initiator of desorption/ionization. In this month's Special Feature, Prof. Wu's and co-authors off er a perspective for using nanoparticles for interaction-assisted laser desorption/ionization of protein signatures from microorganisms.
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