Randomised phase 2 trial of SIR‐Spheres® plus fluorouracil/leucovorin chemotherapy versus fluorouracil/leucovorin chemotherapy alone in advanced colorectal cancer
Journal of Surgical Oncology2004Vol. 88(2), pp. 78–85
Citations Over TimeTop 10% of 2004 papers
Guy van Hazel, Anthony Blackwell, James Anderson, David Price, Paul Moroz, G. Bower, Giuseppe Cardaci, Bruce N. Gray
Abstract
This small phase 2 randomised trial demonstrated that the addition of a single administration of SIR-Spheres to a regimen of systemic fluorouracil/leucovorin chemotherapy significantly increased both treatment related response, time to PD, and survival with acceptable toxicity. The combination of SIR-Spheres plus systemic chemotherapy is now the subject of ongoing trials to further define patient benefit.
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