Biology of colorectal liver metastases: A review
Journal of Surgical Oncology2006Vol. 94(1), pp. 68–80
Citations Over TimeTop 10% of 2006 papers
Abstract
Metastatic growth is a selective, non-random process, which in the case of colorectal cancer, frequently occurs in the liver and is the major cause of cancer related death in these patients. This review summarises attempts to find biological and molecular markers of metastasis and their role in establishment of secondary tumours. Recent evidence suggests that liver metastases are phenotypically different to the primary from which they were derived and thus represent a separate disease entity.
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