Histological necrosis in soft tissue sarcoma following preoperative irradiation
Citations Over Time
Abstract
Abstract Forty‐eight patients with soft tissue sarcomas that presented adverse features for treatment by limb salvage surgery and postoperative irradiation were treated by preoperative irradiation and surgery using a consistent protocol. Following resection, the extent of histological necrosis in the specimen was scored according to the criteria of Willet et al. [11]. Of the 48 cases, 16 (34%) demonstrated Grade 1 response (<50% necrosis), 15 (31%) Grade 2 (50‐80% necrosis), and 17 (35%) Grade 3 (>80% necrosis). There was a trend toward more extensive necrosis in liposarcoma tumors (53% showing Grade 3 response compared to 26% of other sarcomas). Logistic regression analysts demonstrated a significant relationship between necrosis and tumor size ( P < 0.001) with larger tumors having higher grades of necrosis. Tumor grade did not seem to affect the extent of necrosis. In comparison to the previous report of necrosis in soft tissue sarcoma following irradiation [10], the current analysis revealed a smaller proportion of tumors with Grade 3 necrosis. © 1994 Wiley‐Liss, Inc.
Related Papers
- → Centralization of soft tissue sarcoma: Status in Sweden in 1982(1987)15 cited
- → Non-rhabdomyosarcoma Soft-Tissue Sarcoma(2016)5 cited
- [Accomplishments of tumor surgery in soft tissue sarcoma in childhood].(1988)
- → CLINICAL PRACTICE GUIDELINES FOR MANAGEMENT OF SARCOMA: DOES SURGERY AT A SPECIALIZED SARCOMA CENTRE IMPROVE OUTCOMES?(2023)
- → Imaging Appearances of the Most Common Malignant and Benign Lesions from a Regional Soft Tissue Sarcoma Diagnostic Center(2023)