Paraneoplastic chorea with leukoencephalopathy presenting with obsessive–compulsive and behavioral disorder
Movement Disorders2005Vol. 20(11), pp. 1523–1527
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Susanne Muehlschlegel, Michael S. Okun, Kelly D. Foote, Dominique Coco, Anthony T. Yachnis, Hubert H. Fernandez
Abstract
Chorea is a rare manifestation of paraneoplastic disease and is associated with CV2/CRMP-5 antibodies. Obsessive-compulsive disorder and large-scale white matter abnormalities on MRI have not been previously reported in association with these antibodies. We report on a case of CV2 paraneoplastic syndrome with obsessive-compulsive behavior preceding the motor manifestations of chorea with associated leukoencephalopathy on MRI. The literature on paraneoplastic chorea is reviewed.
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