G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort
Movement Disorders2005Vol. 20(12), pp. 1653–1655
Citations Over TimeTop 10% of 2005 papers
José Brás, Rita Guerreiro, Maria Helena Ribeiro, Cristina Januário, Ana Morgadinho, Catarina R. Oliveira, Luı́s Cunha, John Hardy, Andrew Singleton
Abstract
LRRK2 mutations have recently been described in families with Parkinson's disease. Here we show that one of them (G2019S) is present in 6% (7 of 124) unrelated cases of disease in a clinic-based sample series from central Portugal, but not present in 126 controls from the same population. Thus, LRRK2 mutations appear to be a common cause of typical Parkinson's disease and as such will alter clinical practice.
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