Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: Results from a prospective, randomized sham‐controlled trial
Movement Disorders2007Vol. 23(1), pp. 131–134
Citations Over TimeTop 10% of 2007 papers
Joerg Mueller, Inger Marie Skogseid, Reiner Benecke, Andreas Kupsch, Thomas Trottenberg, Werner Poewe, Gerd‐Helge Schneider, Wilhelm Eisner, Alexander Wolters, Jan‐Uwe Müller, Günther Deuschl, Marcus O. Pinsker, Geir Ketil Roeste, Juliane Vollmer‐Haase, Angela Brentrup, Martín Krause, Volker Tronnier, Alfons Schnitzler, J. Voges, Guido Nikkhah, Jan Vesper, Markus Naumann, Jens Volkmann, Deep‐Brain Stimulation for Dystonia Study Group
Abstract
As part of the first randomized, sham-stimulation controlled trial on deep brain stimulation (DBS) in primary segmental or generalized dystonia, health-related quality of life (HRQoL) was assessed by SF-36. After the 3-month sham-controlled phase, significant HRQoL improvement occurred only in the active-stimulation group. The open-label extension phase resulted in a significant improvement in all SF-36 domains following 6 months of neurostimulation. These results demonstrate a favorable impact of DBS on HRQoL in primary dystonia.
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