Effects of contact location and voltage amplitude on speech and movement in bilateral subthalamic nucleus deep brain stimulation | doi.page

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Effects of contact location and voltage amplitude on speech and movement in bilateral subthalamic nucleus deep brain stimulation

Movement Disorders2008Vol. 23(16), pp. 2377–2383

Citations Over TimeTop 10% of 2008 papers

Elina Tripoliti, Ludvic Zrinzo, Irene Martínez‐Torres, Stephen Tisch, Eleanor Frost, Ellie Borrell, Marwan Hariz, Patricia Limousin

Abstract

Subthalamic nucleus deep brain stimulation (STN-DBS) is particularly effective in improving limb symptoms in Parkinson's disease. However, speech shows a variable response. Contact site and amplitude of stimulation have been suggested as possible factors influencing speech. In this double blind study, we assessed 14 patients post bilateral STN-DBS, without medication. Six conditions were studied in random order as follows: stimulation inside the STN at low voltage (2 V) and at high voltage (4 V); above the STN at 2 V and at 4 V, at usual clinical parameters, and off-stimulation. The site of stimulation was defined on the postoperative stereotactic MRI data. Speech protocol consisted of the assessment of intelligibility of the dysarthric speech, maximum sustained phonation, and a 1-minute monologue. Movement was assessed using the UPDRS-III. Stimulation at 4 V significantly reduced the speech intelligibility (P = 0.004) independently from the site of stimulation. Stimulation at 4 V significantly improved the motor function. Stimulation inside the nucleus was significantly more effective than outside the nucleus (P = 0.0006). The significant improvement in movement coupled with significant deterioration in speech intelligibility when patients are stimulated inside the nucleus at high voltage indicates a critical role for electrical stimulation parameters in speech motor control.

Citations Over TimeTop 10% of 2008 papers

Abstract

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