Delayed‐onset Friedreich's ataxia revisited
Movement Disorders2015Vol. 31(1), pp. 62–69
Citations Over TimeTop 11% of 2015 papers
Claire Lecocq, Perrine Charles, Jean‐Philippe Azulay, Wassilios G. Meissner, Myriam Rai, Karine N'Guyen, Yann Péréon, Nelly Fabre, Elsa Robin, Sylvie Courtois, Lucie Guyant‐Maréchal, Fabien Zagnoli, Gabrielle Rudolf, M. Renaud, Mathieu Sévin‐Allouet, Fabien Lesne, Nick Alaerts, Cyril Goizet, Patrick Calvas, Alexandre Eusébio, Claire Guissart, Pascal Derkinderen, François Tison, Alexis Brice, Michel Kœnig, Massimo Pandolfo, Christine Tranchant, Alexandra Dürr, Mathieu Anheim
Abstract
Typical- and delayed-onset Friedreich's ataxia are different and Friedreich's ataxia is heterogeneous. Late-onset Friedreich's ataxia and very-late-onset Friedreich's ataxia appear to belong to the same clinical and molecular continuum and should be considered together as "delayed-onset Friedreich's ataxia." As the most frequently inherited ataxia, Friedreich's ataxia should be considered facing compatible pictures, including atypical phenotypes (spastic ataxia, retained reflexes, lack of dysarthria, and lack of extraneurological signs), delayed disease onset (even after 60 years of age), and/or slow disease progression.
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