Multiomics Analyses Identify Genes and Pathways Relevant to Essential Tremor
Movement Disorders2020Vol. 35(7), pp. 1153–1162
Citations Over TimeTop 19% of 2020 papers
Calwing Liao, Faezeh Sarayloo, Daniel Rochefort, Gabrielle Houle, Fulya Akçimen, Qin He, Alexandre D. Laporte, Dan Spiegelman, Werner Poewe, Daniela Berg, Stefanie H. Müller, Franziska Hopfner, Günther Deuschl, Gregor Kuhlenbäeumer, Alex Rajput, Patrick A. Dion, Guy A. Rouleau
Abstract
We found that calcium-related pathways were enriched across the GWGAS, TWAS, and transcriptome. SHF was shown to have significantly decreased expression, and the pheWAS showed it was associated with blood pressure medication. The treatment of cells with propranolol showed that the drug restored levels of SHF. Overall, our findings highlight the power of integrating multiple different approaches to prioritize ET pathways and genes. © 2020 International Parkinson and Movement Disorder Society.
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