High Glucosylceramides and Low Anandamide Contribute to Sensory Loss and Pain in Parkinson's Disease
Movement Disorders2020Vol. 35(10), pp. 1822–1833
Citations Over TimeTop 10% of 2020 papers
Katharina Klatt‐Schreiner, Lucie Valek, Jun‐Suk Kang, Alexander Khlebtovsky, Sandra Trautmann, Lisa Hahnefeld, Yannick Schreiber, Robert Gurke, Dominique Thomas, Annett Wilken‐Schmitz, Sabine Wicker, Georg Auburger, Gerd Geißlinger, Jörn Lötsch, Waltraud Pfeilschifter, Ruth Djaldetti, Irmgard Tegeder
Abstract
Our data suggest that PD-associated sensory neuropathies and PD pain are in part caused by accumulations of glucosylceramides, raising the intriguing possibility of reducing PD pain and sensory loss by glucocerebrosidase substituting or refolding approaches. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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