STAT3: A critical transcription activator in angiogenesis
Citations Over TimeTop 10% of 2007 papers
Abstract
Angiogenesis, the formation of new blood vessels from the pre-existing vasculature, is a complex multistage process regulated by a number of signal transduction pathways. Accumulating evidence suggests that signal transducer and activator of transcription (STATs), mainly STAT3, play an important role in angiogenesis under both physiological and pathological conditions in addition to cell survival, proliferation, differentiation, and oncogenesis. STAT3, as a critical multifunctional mediator, regulates many aspects of angiogenesis at the transcriptional level. This review will highlight the pivotal role of STAT3 in well-studied tumorous angiogenesis and cardiac angiogenesis, and summarize various potential mechanisms utilized by STAT3 to regulate the transcriptional activation of VEGF.
Related Papers
- → The vasohibin family: a novel family for angiogenesis regulation(2012)113 cited
- → The vasohibin family: Novel regulators of angiogenesis(2012)27 cited
- A novel in vitro angiogenesis model based on a microfluidic device(2011)
- → Angiogenesis in Cardiovascular Disease(2007)3 cited
- → A PlGF-1 Derived Peptide Inhibits Angiogenesis via HIF-1β/VEGF Pathway(2016)