Localization of anatomical changes in patients during proton therapy with in‐beam PET monitoring: A voxel‐based morphometry approach exploiting Monte Carlo simulations
Medical Physics2021Vol. 49(1), pp. 23–40
Citations Over TimeTop 12% of 2021 papers
A. Kraan, Andrea Berti, Alessandra Retico, G. Baroni, G. Battistoni, Nicola Belcari, P. Cerello, Mario Ciocca, Micol De Simoni, D. Del Sarto, M. Donetti, Yunsheng Dong, A. Embriaco, V. Ferrero, E. Fiorina, M. Fischetti, Gaia Franciosini, Giuseppe Giraudo, Francesco Laruina, Davide Maestri, M. Magi, Giuseppe Magro, Carlo Mancini Terracciano, M. Marafini, I. Mattei, E. Mazzoni, Paolo Mereu, R. Mirabelli, Alfredo Mirandola, M. Morrocchi, S. Muraro, Alessandra Patera, V. Patera, F. Pennazio, Angelo Rivetti, M. Rolo, V. Rosso, A. Sarti, A. Schiavi, A. Sciubba, E. Solfaroli Camillocci, Giancarlo Sportelli, Sara Tampellini, M. Toppi, G. Traini, S.M. Valle, Francesca Valvo, Barbara Vischioni, Viviana Vitolo, Richard Wheadon, M.G. Bisogni
Abstract
The statistical method presented in this work is a promising method to apply to PET monitoring data to reveal interfractional morphological changes in patients, occurring over the course of treatment. Based on simulated in-beam PET treatment monitoring images, we showed that with our method it was possible to correctly identify the regions that changed. Moreover we could quantify the changes, and visualize them superimposed on the CT scan. The proposed method can possibly help clinical personnel in the replanning procedure in adaptive proton therapy treatments.
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