Commissioning a 250 MeV research beamline for proton FLASH radiotherapy preclinical experiments
Medical Physics2023Vol. 50(7), pp. 4623–4636
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Yunjie Yang, Minglei Kang, Chin‐Cheng Chen, Lei Hu, Francis T. S. Yu, Pingfang Tsai, Sheng Huang, Jiayi Liu, Ryan C. Turner, Brian Shen, Shaakir Hasan, Arpit M. Chhabra, J. Isabelle Choi, Brett I. Bell, Michael Pennock, Wolfgang A. Tomé, Chanda Guha, Charles B. Simone, Haibo Lin
Abstract
A 250 MeV proton research beamline was successfully commissioned and characterized. Challenges due to the saturated monitor ionization chamber were mitigated by scaling MU and using an in vivo dosimetry system. A simple aperture system was designed and validated to provide sharp dose fall-off for small animal experiments. This experience can serve as a foundation for other centers interested in implementing FLASH radiotherapy preclinical research, especially those equipped with a similar saturated MIC.
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