In vivo31P nuclear magnetic resonance studies of T1 and T2 relaxation times in rat brain and in rat brain tumors implanted to nude mice
Citations Over TimeTop 10% of 1987 papers
Abstract
31P NMR spin-lattice (T1) and spin-spin (T2) relaxation times of phosphocreatine, ATP, inorganic phosphate, and phosphomonoesters have been measured in vivo at 4.7 T in rat brain and rat brain tumors implanted on nude mice. The relaxation data were acquired using a phase-cycled saturation-recovery spin-echo sequence. The problems associated with the phase modulation of the ATP lines by the homonuclear coupling constants were overcome by using selective refocusing pulses for the T2 measurements. In all the metabolites, large differences (1 to 2 orders of magnitude) are observed between the two relaxation times. T1 values in rat brain tumors are 30 to 90% longer than their counterparts in normal rat brain. T2 values follow the same trend with smaller variations except for phosphocreatine values which seem much less sensitive to the metabolic state of the tissues.
Related Papers
- → J‐compensated PGSE: an improved NMR diffusion experiment with fewer phase distortions(2009)47 cited
- → Effect of homonuclear J modulation on 19F spin‐echo images(1991)15 cited
- → Spin-echo methods for the determination of 31P transverse relaxation times of the ATP NMR signals in vivo(1994)11 cited
- → Real figure of two-dimensional spin-echo NMR spectra for a homonuclear two-spin system in rotating solids(2001)1 cited
- → Theoretical study of a simple rotational‐echo double‐resonance NMR for homonuclear spin‐1/2 pairs(2015)