In vivo detection of brain glycine with echo‐time‐averaged 1H magnetic resonance spectroscopy at 4.0 T

Citations Over TimeTop 10% of 2006 papers

Abstract

A single-voxel proton magnetic resonance spectroscopy ((1)H-MRS) method is described that enables the in vivo measurement of endogenous brain glycine (Gly) levels in human subjects. At 4.0 T, TE-averaging (1)H-MRS dramatically attenuates the overlapping myo-inositol (mI) resonances at 3.52 ppm, permitting a more reliable measure of the Gly singlet peak. This methodology initially is described and tested in phantoms. The phantom data infers that the 3.55-ppm peak predominantly is Gly with a smaller contribution from mI. The composite resonance thus is differentiated from pure Gly and mI and is labeled Gly*. The mI contribution was calculated as <2% of the total Gly* signal for a 1:1 mI/Gly mixture. The technique subsequently was used to acquire TE-averaged (1)H-MRS data from the occipital cortex of healthy control subjects. The resultant spectra closely resembled experimental phantom data. LC-model analysis provided a means for quantifying TE-averaged (1)H-MRS spectra and a mean test-retest variability measure of 15% was established for brain Gly* levels in studies of six healthy subjects.

Related Papers

• → Diffusion measurements using the second echo(2018)5 cited
• Magnetoacoustic excitation of nuclear spin echo(1976)
• → Nuclear spin echo in crystals with frequency pulling(1977)
• MRI of the lung: comparison of ultrashort-echo-time (UTE) to zero-echo-time (ZTE) | Article Information | J-GLOBAL(2011)
• → The metal artifact and susceptibility effect in Fast Spin Echo method : Comparison between Fast Spin Echo and Conventional Spin Echo Sequence(Program of 23rd Autumn Meeting)(1995)