Genetic variants in LEP, LEPR, and MC4R explain 30% of severe obesity in children from a consanguineous population
Obesity2015Vol. 23(8), pp. 1687–1695
Citations Over TimeTop 10% of 2015 papers
Sadia Saeed, Amélie Bonnefond, Jaida Manzoor, Faiza Shabir, Hina Ayesha, Julien Philippe, Emmanuelle Durand, Hutokshi Crouch, Olivier Sand, Muhammad Ashar Ali, Taeed A. Butt, Ahsan Waheed Rathore, Mario Falchi, Muhammad Arslan, Philippe Froguel
Abstract
The prevalence of pathogenic mutations in genes known to directly influence leptin-melanocortin signaling is 30% in our cohort. The results of this study emphasize the desirability of undertaking systematic and in-depth genetic analysis of cases with severe obesity in specific consanguineous populations.
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