Compromised responses to dietary methionine restriction in adipose tissue but not liver of ob/ob mice
Obesity2015Vol. 23(9), pp. 1836–1844
Citations Over TimeTop 14% of 2015 papers
Kirsten P. Stone, Desiree Wanders, Lucie F. Calderon, Stephen B. Spurgin, Philipp E. Scherer, Thomas W. Gettys
Abstract
These findings show that diet-induced changes in hepatic lipid metabolism are independent of weight loss and remodeling of WAT and are not required for insulin sensitization. In contrast, the failure of ob/ob mice to mount a normal thermogenic response to MR suggests that the compromised responsiveness of adipose tissue to SNS input is an important component of the inability of the diet to correct their obesity and insulin resistance.